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Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study.

1Human Nutrition Research Centre,Institute of Cellular Medicine,Newcastle University,Newcastle Upon Tyne NE1 7RU,UK. 2Center for Nutrition Research,University of Navarra,31008 Pamplona,Spain. 4UCD Institute of Food and Health,University College Dublin,Belfield,Dublin 4,Republic of Ireland. 5Department of Human Biology,NUTRIM School of Nutrition and Translational Research in Metabolism,Maastricht University Medical Centre,Maastricht 6229 HX,The Netherlands. 6Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research,University of Reading,Reading RG6 6AP,UK. 7ZIEL Research Center of Nutrition and Food Sciences,Biochemistry Unit,Technische Universität München,85435 Freising,Germany. 8Department of Nutrition and Dietetics,Harokopio University,Kallithea 17671,Greece. 9National Food & Nutrition Institute (IZZ),Warsaw 02903,Poland. 10Department of Nutrition,Institute of Basic Medical Sciences, Faculty of Medicine,University of Oslo,0372 Oslo,Norway.

The British journal of nutrition. 2016;(3):440-8
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Abstract

The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AA v. TT: +1·4 cm; P=0·003) and BMI (+0·9 kg/m2; P=0·001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 1·4 kg/m2 greater BMI (Ptrend=0·028) and 3·1 cm greater WC (Ptrend=0·045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.

Methodological quality

Publication Type : Randomized Controlled Trial

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